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DHA increases Angptl4 gene expression and reduces LPL activity in a PPARγ-dependent manner in adipocytes

Journal article reports that docosahexaenoic acid (DHA) increases Angptl4 gene expression and reduces lipoprotein lipase (LPL) activity in adipocytes via a PPARγ-dependent mechanism. No further experimental details or implications were included in the supplied source excerpt.

Figure 3. External agents capable of inducing the browning process in adipose tissue. β3 receptor activation regulate the transcription and activation of genes linked to mitochondrial activity and fat storage. The exposure to excessive cold induces release of catecholamines by the central nervous system (CNS), which will act on β3 adrenergic receptors on adipocytes initiating the signaling cascade. Activation of cAMP through the binding of catecholamines at adipocytes receptors will activate pro
Illustrative image: Figure 3. External agents capable of inducing the browning process in adipose tissue. β3 receptor activation regulate the transcription and activation of genes linked to mitochondrial activity and fat storage. The exposure to excessive cold induces release of catecholamines by the central nervous system (CNS), which will act on β3 adrenergic receptors on adipocytes initiating the signaling cascade. Activation of cAMP through the binding of catecholamines at adipocytes receptors will activate pro — Corrêa, L.H.; Heyn, G.S.; Magalhaes, K.G./Wikimedia Commons, CC BY 4.0

Categories: science-and-space

Generated scores

Scores are based on the cited reporting and use a 1–10 scale. Read the methodology.

Confidence
3/10
Geographic reach
1/10
Global importance
3/10
Impact magnitude
2/10
Positivity
5/10
Urgency
1/10

Why it matters

The article documents a molecular effect of DHA on adipocyte gene expression and enzyme activity.

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