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P3.03.18 Single-Cell Transcriptomic Analyses of Lung Immune Cells Reveal That Mitf-Driven Plcb1HighMacrophages Induce Radiation-Induced Lung Injury

A journal article reports single-cell transcriptomic analyses indicating MITF-driven, PLCB1-high macrophages are associated with radiation-induced lung injury. Publisher is Elsevier BV and the article was published 2025-10-01.

Figure 1. Tuberculosis pathogenesis and disease progression. Mycobacterium tuberculosis infection initiates with inhalation of droplets that carry bacteria and their uptake by alveolar macrophages. Innate immune responses characterize the initial phase of infection, with recruitment of inflammatory cells in the lung. Bacterial dissemination to the draining lymph node leads to T cell priming and expansion of antigen-specific T cells. Recruitment of activated macrophages, neutrophils, T cells, and
Illustrative image: Figure 1. Tuberculosis pathogenesis and disease progression. Mycobacterium tuberculosis infection initiates with inhalation of droplets that carry bacteria and their uptake by alveolar macrophages. Innate immune responses characterize the initial phase of infection, with recruitment of inflammatory cells in the lung. Bacterial dissemination to the draining lymph node leads to T cell priming and expansion of antigen-specific T cells. Recruitment of activated macrophages, neutrophils, T cells, and — Sinigaglia, A.; Peta, E.; Riccetti, S.; Venkateswaran, S.; Manganelli, R.; Barzon, L./Wikimedia Commons, CC BY 4.0

Categories: science-and-space, public-health

Generated scores

Scores are based on the cited reporting and use a 1–10 scale. Read the methodology.

Confidence
6/10
Geographic reach
1/10
Global importance
3/10
Impact magnitude
2/10
Positivity
2/10
Urgency
2/10

Why it matters

Identifies a specific macrophage population linked to radiation-induced lung injury.

Sources

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