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P3.03.19 SFRP2highCAFs Trigger CD8+T Cell Apoptosis to Sustain Abscopal Resistance to Radioimmunotherapy in Lkb1-Mutant Lung Tumors

A journal article (Elsevier BV) reports that SFRP2-high cancer-associated fibroblasts induce CD8+ T cell apoptosis and sustain abscopal resistance to radioimmunotherapy in Lkb1-mutant lung tumors. The source is identified as a journal article published on 2025-10-01.

Fig 1. The heterogeneity of fibroblasts could be attributed to the multiple origins of the precursor cells, the phenotypical diversity of subsets and the distinct function of each subset. Potential cellular sources include local tissue resident stellate cells and normal fibroblasts and nonfibroblast lineage or recruited bone marrow-derived mesenchymal stem cells (MSCs) and macrophages. The main subsets of CAFs include myCAFs, iCAFs and apCAFs, which exhibit different biological features and resu
Illustrative image: Fig 1. The heterogeneity of fibroblasts could be attributed to the multiple origins of the precursor cells, the phenotypical diversity of subsets and the distinct function of each subset. Potential cellular sources include local tissue resident stellate cells and normal fibroblasts and nonfibroblast lineage or recruited bone marrow-derived mesenchymal stem cells (MSCs) and macrophages. The main subsets of CAFs include myCAFs, iCAFs and apCAFs, which exhibit different biological features and resu — Yang, D., Liu, J., Qian, H. et al/Wikimedia Commons, CC BY 4.0

Categories: science-and-space, public-health

Generated scores

Scores are based on the cited reporting and use a 1–10 scale. Read the methodology.

Confidence
6/10
Geographic reach
1/10
Global importance
3/10
Impact magnitude
3/10
Positivity
2/10
Urgency
2/10

Why it matters

The article describes a mechanism that could affect the effectiveness of radioimmunotherapy in Lkb1-mutant lung tumors.

Sources

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