First published 10/3/2026, 1:33:15 AM · Last updated 10/3/2026, 1:33:15 AM

P35-9 Targeting lysine-specific demethylase 1 as a valid therapeutic approach for MPNST therapy

A journal article proposes inhibiting lysine-specific demethylase 1 as a therapeutic strategy for malignant peripheral nerve sheath tumors (MPNST). Publisher metadata identifies Elsevier BV and the item as a journal article published 2025-10-01.

Illustrative image: "Panel (a) illustrates the overlap between genes identified in transcriptome-wide association studies (TWAS) across various cell types or species, and the top 1,000 CpGs that have increased/decreased with age in EWAS across mammalian tissues. TWAS results are stratified by tissue type, including all tissues, blood, skin, liver, muscle, brain, and cerebral cortex. Overlapping genes with P < 0.05 are reported. Similarly, Panel (b) demonstrates the overlaps between the top 2.5% genes implicated — Authors of the study: A. T. Lu, Z. Fei, A. Haghani, T. R. Robeck, J. A. Zoller, C. Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V. A. Acosta-Rodriguez, D. M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C. S. Baker, G. Banks, K. Belov, N. C. Bennett, P. Black, D. T. Blumstein, E. K. Bors, C. E. Breeze, R. T. Brooke, J. L. Brown, G. G. Carter, A. Caulton, J. M. Cavin, L. Chakrabarti, I. Chatzistamou, H. Chen, K. Cheng, P. Chiavellini, O. W. Choi, S. M. Clarke, L. N. Cooper, M./Wikimedia Commons, CC BY 4.0

Categories: science-and-space, public-health

Generated scores

Scores are based on the cited reporting and use a 1–10 scale. Read the methodology.

Confidence: 4/10How certain the assessment is based on the clarity and evidence in the cited reporting.
Geographic reach: 1/10How widely the event reaches, from a local area (1) to worldwide impact (10).
Global importance: 3/10The event's broader significance, from limited importance (1) to major global importance (10).
Impact magnitude: 3/10The scale or severity of the real-world impact, from minor (1) to extreme (10).
Positivity: 7/10How harmful or beneficial the event is, from strongly harmful (1) to strongly positive (10).
Urgency: 2/10How time-sensitive the event is, from low urgency (1) to immediate attention needed (10).

Why it matters

The article presents a potential new treatment approach for MPNST that is relevant to cancer therapy research.

Sources

P35-9 Targeting lysine-specific demethylase 1 as a valid therapeutic approach for MPNST therapy

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