First published · Last updated
PNPLA3-I148M is a neomorph that interferes with two primary hepatic triglyceride clearance pathways
A peer-reviewed article published by Elsevier on 2025-10-01 reports that the PNPLA3 I148M variant functions as a neomorphic protein that disrupts two main liver triglyceride clearance pathways. The source provided is the article title, publisher, and publication date without further experimental details.
Categories: science-and-space, public-health
Generated scores
Scores are based on the cited reporting and use a 1–10 scale. Read the methodology.
- Confidence
- 5/10
- Geographic reach
- 1/10
- Global importance
- 3/10
- Impact magnitude
- 2/10
- Positivity
- 3/10
- Urgency
- 2/10
Why it matters
The result pertains to mechanisms of hepatic triglyceride metabolism and is relevant to related biomedical research.

